In Search of the Ideal Tumor Marker for Epithelial Ovarian Cancer: Serum Antigen CA-125 versus HE4, and Others; Current Status and Clinical Utility
نویسندگان
چکیده
Flavia Morales-vásquez1*, Horacio Noé lópez-Basave2, carMeN MéNdez4, dolores Gallardo riNcóN1, claudia caNo BlaNco1, WeNdy r. Muñoz1, José luis aGuilar-poNce3 aNd JaiMe G. de la Garza-salazar1 1 Department of Medical Oncology, 2Division of Surgical Oncology; 3Division of Internal Medicine, National Cancer Institute, Mexico City, Mexico; 4Embryology Laboratory, National Autonomous University of Mexico, Mexico City, Mexico
منابع مشابه
FoxP3+ Regulatory T Cells in Peripheral Blood of Patients with Epithelial Ovarian Cancer
Background: Ovarian cancer is the fifth leading cause of death from malignancy in women. CD4 +CD25+FoxP3+ regulatory T (Treg) cells are a subset of T lymphocytes with great inhibitory impact on immune response. Objectives: To investigate the percentage of CD4 +CD25+FoxP3+ regulatory T cells in the peripheral blood of the Iranian patients with epithelial ovarian cancer compared to healthy women ...
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BACKGROUND Human epididymis protein 4 (HE4), a precursor of human epididymis protein, has been proposed as a tumor marker for ovarian cancer. We evaluated HE4 in comparison with cancer antigen 125 (CA 125) in healthy individuals and in patients with benign and malignant diseases. METHODS CA 125 and HE4 serum concentrations were determined in 101 healthy individuals, 535 patients with benign p...
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Three decades have elapsed since Robert Bast, working in the Gynecologic Research laboratory of Robert Knapp at Harvard, developed an antibody directed to an antigen in ovarian cancer cells, leading to the seminal publication on cancer antigen 125 (CA 125) for the monitoring of patients with ovarian cancer.[1] In the ensuing years, measuring serum CA 125 had a central role in the management of ...
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OBJECTIVE To compare accuracy of serum human epididymis protein 4 (HE4) levels with cancer antigen 125 (CA-125) levels as biomarkers for ovarian cancer. METHODS The study population included 94 Korean women, including 32 patients with a diagnosis of ovarian cancer and 62 patients with a diagnosis of benign ovarian tumor. All diagnoses were confirmed by histopathological analysis. Serum HE4 le...
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The aim of this study was to evaluate serum human epididymis protein 4 (HE4) concentrations for the diagnosis and preoperative prediction of optimal debulking in epithelial ovarian cancer. The concentrations of serum HE4 and CA125 in 180 epithelial ovarian cancer patients, 40 benign ovarian tumor patients and 40 healthy female subjects were determined using enzyme-linked immunosorbent assays (E...
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